Even though alternative models are available, such as animal models or ex vivo models, in vitro models offer higher experimental flexibility and reproducibility, making them a valuable tool for the understanding of pathophysiological mechanisms of several diseases, such as CVDs
N Engl J Med 380:347357 Cannon CP, Pratley R, Dagogo-Jack S, Mancuso J, Huyck S, Masiukiewicz U, Charbonnel B, Frederich R, Gallo S, Cosentino F, Shih WJ, Gantz I, Terra SG, Cherney DZI, McGuire DK (2020) VERTIS CV Investigators
Unlike traditional cell therapies that require harvesting and re-engineering a patient's cells outside the body, Sail's platform is designed to reprogram immune cells directly inside the body, an approach the companies say could make CAR T manufacturing simpler and more scalable while delivering durable, potentially curative results
But professional medical guidance is essential before considering these treatments