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Although preliminary regulatory-led analyses of post-marketing data have not found conclusive evidence of a causal link [14], and in the absence of evidence from large, randomised clinical trials, observational studies adequately designed to assess the comparative safety of treatments, employing an active comparator, new user design, are warranted to evaluate the risk of SIS in individuals treated with GLP-1RA
This has been attributed to differences in neuronal circuitry linked to the complex interplay of genetics, metabolic stress and environmental factors, which helps explain why PD emerges and develops in different ways in different individuals (Wong and Krainc, 2017
The T m s were calculated by using the maximum (or minimum) of the first derivative at 350 nm
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