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Recent clinical studies reported that SGLT-2is improved hypertension and atrial fibrillation by modulating the overstimulated renin-angiotensin-aldosterone system (RAAS) and suppressing the sympathetic nervous system (SNS) by directly/indirectly acting on the rostral ventrolateral medulla

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Furthermore, its role in the immune response is exemplified in cystic fibrosis

Its an option many in the United States are turning to over cost or supply problems with the brand name drugs but which experts and officials have flagged for possible risks