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The supernatant was loaded onto a Strep-Tactin XT 4flow high-capacity resin (IBA Lifesciences), after which the resin was washed with 15-20 ml of freshly prepared lysis buffer

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Additionally, in order to explore the mechanism of action being neuronal apoptosis, the research team assessed levels of neuroinflammation and glial activation by detecting levels of IL-1-beta, IL-10, and TNF-alpha in the brain

Skin biopsies performed before and after treatment and 12 weeks later showed a significant increase in collagen and elastic fiber density