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The FDA label explicitly states this knowledge gap, requiring healthcare providers and patients to make individualized decisions weighing maternal treatment needs against theoretical infant risks
Lack of Specific Studies on Kidney Stones As of now, there are no specific large-scale studies that focus solely on the relationship between tirzepatide and kidney stone formation
Not Eating Enough Protein Insufficient protein may contribute to muscle loss during weight reduction
Besides, Akt phosphorylates and inactivates GSK3, FOXO, and TSC1/2, leading to activation of Wnt signaling, inhibition of apoptosis, and activation of mTORC1, respectively [47]
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