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Patients receiving sitagliptin with metformin immediate-release and insulin had significant improvements in A1C, FPG and 2-hour PPG compared to patients receiving placebo with metformin immediate-release and insulin (Table 13)

Consider the risk of abuse before prescribing and monitoring for signs of misuse and addiction

A review of pivotal clinical trials for semaglutide (STEP, SUSTAIN), dulaglutide (REWIND), liraglutide (LEADER), and tirzepatide (SURPASS, SURMOUNT) does not identify muscle cramps as occurring at significantly higher rates compared to placebo groups

Cost Comparison for Research Research compound economics differ substantially between these categories