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Because retatrutide includes GLP-1 agonism (which semaglutide was providing) plus GIP and glucagon agonism, the transition should not result in loss of appetite suppression during the switch
That means medically supervised weight loss with proper follow-up, and a plan that includes healthy nutrition and lifestyle changes- not just injections
You might lean towards Zepbound if: Youre dealing with obstructive sleep apnea Youve hit a plateau on another GLP-1 like Wegovy Youre looking for more powerful appetite control You still feel hungry, even while on medication Wegovy may be the better fit if: You have cardiovascular disease and want a medication that supports heart health Youve had success with semaglutide in the past Your insurance is more likely to cover Wegovy The good news
Your small intestine releases GLP-1 after you eat
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