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The dosing schedule involves gradual titration from lower doses to the full dose of two tablets twice daily (32 mg naltrexone/360 mg bupropion) over four weeks

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DPP-4 inhibitors [37], which elevate incretin hormone levels to maintain glucose homeostasis, have yielded mixed findings regarding their association with intestinal obstruction: a smaller study of 40,615 patients indicated a potential risk [15], while a larger cohort study of 190,321 patients across three countries found no increased risk [16]