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High-intensity interval training or long-distance running may not be practical when you are eating less and adjusting to a new medication

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Instruct patients if symptoms of allergic reactions (including skin rash, hives and swelling of the face, lips, tongue and throat that may cause difficulty in breathing or swallowing) occur, patients should discontinue alogliptin and pioglitazone tablets and seek medical advice promptly [see Warnings and Precautions (5.3)]

Some patients need slower titration