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The acetyl group protects SAG from enzymatic cleavage in the upper GI tract, allowing a significantly higher proportion of SAG to reach the small intestine intact than unmodified GSH
Its defining structural feature is the gamma-glutamyl linkage: the glutamate residue is joined through its side-chain carboxyl rather than the usual alpha-peptide bond, which makes the molecule resistant to most intracellular peptidases and means it is cleaved almost exclusively by gamma-glutamyl transpeptidase at the outer cell surface (Zhang, Forman and Choi, Methods in Enzymology, 2005)
Sarah Usher Commercial & Operations Director Sarah Usher Sarah joined our team 8 years ago bringing a fresh perspective to the life work balance we all needed
Glutathione may help address hyperpigmentation and uneven skin tone by inhibiting melanin synthesis, providing antioxidant protection, detoxifying and improving skin clarity, increasing skin brightness, supporting collagen production, and improving skin texture
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