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3.4 Adverse events Three subjects experienced intermittent diarrhea, bloating and nausea before the initiation of semaglutide treatment (timepoint 1), but the symptoms were not severe enough to warrant discontinuation of metformin therapy

As diabetes progresses, total sperm count and motility continuously decline, with corresponding damage and atrophy of the seminiferous tubules, leading to reduced epithelial cell layers and even complete loss of reproductive function [30]

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