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This would correspond to complete protection in vivo at nAb levels at least 500 times higher than the IC 50 as measured in vitro or 200 times higher than the IC 80
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In the context of AD, the focus should be on individuals at risk, such as those with MCI, subjective cognitive decline, elders with positive A or tau biomarkers, APOE -4-carriers or healthy elderly individuals with high-risk scores [105]
Moreover, leading players have gotten multiple extensions by making incremental improvements to their branded drugs
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