Rosiglitazone evaluated for cardiovascular outcomes in oral agent combination therapy for type 2 diabetes (RECORD): a multicentre, randomised, open-label trial
In conclusion, the overuse of FQs and the growing number of reports of chronic adverse reactions (ADRs), including potential FQAD, are the main reasons to avoid FQs when other safer alternatives are available
Aside from C1QBP, insulin/IGF-1 can also alter the nuclear factor-kB (NF-kB) signal pathway, Polo-like kinase 1 (PLK1), NADPH oxidase 4 (NOX4), and mammalian target of rapamycin (mTOR) to reverse apoptosis, repair DNA and induce multi-drug resistance gene (Lee et al., 2007
Its mechanism of action involves the reversible inhibition of pancreatic lipases, which are essential enzymes responsible for the hydrolysis of dietary triglycerides into absorbable free fatty acids and monoglycerides