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However, only about a half of newly generated cells survive in the long term to integrate in the preexisting neural network, and a subgroup of these neurons will show abnormal morpho-functional development, including aberrant migration, bipolar morphology, or an abnormal functional development

[56] [57] Economic evaluations of GLP-1 receptor agonists for non-diabetic obesity have reported incremental cost-effectiveness ratios well above common willingness-to-pay thresholds, including estimates in the approximate range of $237,000-$483,000 per quality-adjusted life-year in some U.S.-based models

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