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In immature human dendritic cells, progesterone increased expression of mitochondrial complex II-V genes (succinate dehydrogenase complex iron sulfur subunit B, [SDHB], succinate dehydrogenase complex subunit C [SDHC], ubiquinol-cytochrome C reductase complex III subunit VII [UQCRQ], cytochrome c oxidase subunit II [COX II], and ATP synthase F1 subunit alpha [ATP5A]), and mitochondrial pyruvate carrier 1 (MPC1) (194)
By weakening the masseter muscles, botox reduces the force and frequency of these actions, leading to less strain on the TMJ
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