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Activation of the renin-angiotensin-aldosterone system (RAAS) and elevated endothelin-1 levels promote vasoconstriction, fluid retention, and increased afterload
For detailed side effect management strategies , proper nutrition and hydration typically resolve most issues
That makes sense given that the anti-inflammatory effects work through pathways independent of weight loss you dont need to lose 15 percent of your body weight to get the benefit
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