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2 Literature search strategy Recent literature of this narrative review was identified through searches of Web of Science Core Collection, PubMed, Science Direct, and Google Scholar using combinations of keywords related to flavonoid biosynthesis, phenylpropanoid pathway, structure-activity relationships, biotic stress, abiotic stress, combined stress, secondary metabolism, redox homeostasis, phytohormone signaling, metabolic flux, metabolic branch points, pathway competition, metabolic trade-off, multi-omics, artificial intelligence, machine learning, CRISPR/Cas systems, and metabolic engineering
NAD+ controls neural stem cell fate in the aging brain