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Second, the micro-channels created by needling dramatically improve absorption of both PTD-DBM and valproic acid, allowing more of each compound to reach target cells
It also comes with potential side effects, albeit rare ones, including breathing issues (with spray products) and skin inflammation in some people
Phase 3 trials (large human trials with thousands of participants) are still running, and Lilly plans to apply for regulatory approval once the TRIUMPH programme publishes its results across 2026
If not closely managed, this can lead to side effects such as joint pain, fluid retention, insulin resistance, and other concerns
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