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The problem with inexpensive glutathione supplements is that GSH is inherently unstable: the thiol group of the molecule oxidises relatively quickly to the inactive GSSG form upon exposure to heat, light or oxygen

Patients with pancreatic insufficiency may have reduced cobalamin absorption (because pancreatic enzymes normally assist with the displacement of salivary haptocorrin binding protein by intrinsic factor), although such patients rarely become cobalamin deficient

Suggested benefits for mood, cognition, and possibly conditions like traumatic brain injury, Parkinsons disease, and depression, but these claims are not substantiated in humans358

This is a judgment call that depends on specific circumstances and how questions are phrased