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For instance, compounds such as curcumin, resveratrol, and epigallocatechin gallate have been investigated in Phase I and Phase II studies for indications including cancer, metabolic disorders, and inflammatory diseases

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Despite RIC is classified as an autosomal recessive disorder, five of the seven Japanese patients with RIC in a retrospective study were compound heterozygous, and two were simple heterozygous with a single variant of the ATP8B1 or ABCB11 genes