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Xiang Y, Xiaoshan Z, Li W, Zhang R, Xingxiang P, Shuhong W, Lei L, Tong P, Wang J, Qinghe M, Luc G, Minna J, Roth JA, Swisher SG , Heymach JV, Bingliang F

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Regarding Diabetes mellitus management, the effect of metformin, a classic anti-diabetic drug, on epilepsy is controversial: on the one hand, studies have confirmed that it, as an AMPK agonist, activates thalamic AMP-activated protein kinase, thereby enhancing metabotropic GABAB receptor function and ultimately promoting absence epileptic seizures (95)

Rationale and design of the expanded combination of evolocumab plus empagliflozin in diabetes: EXCEED-BHS3 trial