chest pain glp 1 Bridging the gap between GLP1-receptor agonists and cardiovascular outcomes: evidence for the role of tirzepatide Breakthrough of the Year: GLP-1

Endogenously, GLP-1 is secreted by intestinal L cells in response to food, and has multiple roles: enhancing insulin secretion (in a glucose-dependent way), reducing glucagon secretion, slowing gastric emptying, increasing feelings of fullness/satiety, and improving glucose disposal in peripheral tissues

Subcutaneous delivery supports controlled systemic exposure and extended receptor engagement in experimental protocols

there is also data to suggest that slower titration regimens (employed in GLP-1-insulin combo therapies), may reduce rates of nausea and vomiting further

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