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97 found that isocaloric protein restriction down to 12E% over 3 months was not able to reproduce the beneficial metabolic changes induced by CR in male C57BL/6 mice, in particular the decrease in IGF-1 concentrations

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Using liquid chromatography-mass spectrometry, levels of L-carnitine and associated metabolites: -butyrobetaine (GBB), crotonobetaine, as well as acylcarnitines, were evaluated at 10-, 25-, and 50-weeks, in the brain and the periphery, in a targeted replacement mouse model of human APOE (APOE-TR)

This overexpression reduces intracellular GSH levels, causing an imbalance in the cellular redox state and a consequent increase in ROS