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Extreme temperatures, humidity, and sun exposure can change lip color

Brain activity mapping in Mecp2 mutant mice reveals functional deficits in forebrain circuits, including key nodes in the default mode network, that are reversed with ketamine treatment

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A brown spot that appears suddenly on the lip is most often a labial melanotic macule triggered by accumulated UV damage finally crossing a visible threshold, a localized inflammatory event (a healed cold sore, a friction point, a burn from hot food or drinks), or hormonal fluctuations