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Frequencies range from weekly to monthly, depending on your goals and baseline levels

The dual GIP/GLP-1 receptor agonism that suppresses appetite, enhances satiety, and improves insulin secretion gradually diminishes

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[2] Adverse GI effects reported during spironolactone therapy include nausea, vomiting, cramping, diarrhea, gastritis, abdominal pain, gastric bleeding, and ulceration.2 Adverse nervous system effects that have been reported in patients receiving spironolactone therapy include headache, dizziness, drowsiness, lethargy, ataxia, and mental confusion