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Secondly, we implemented several design features to mitigate biases: we defined a causal framework, used direct acyclic graphs to guide the selection of confounders, specified new user, active comparator target trials, and used inverse probability weighting to adjust for a comprehensive set of covariates from multiple data domains

The SURMOUNT-1 trial showed that while average weight loss at 72 weeks reached 1521% depending on dose, the trajectory was not linear, with many participants experiencing temporary plateaus

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