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It is released by intestinal L-cells after a meal and, separately, by preproglucagon neurons in the nucleus tractus solitarius of the brainstem, which gives the peptide both a peripheral endocrine role and a central neural one
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Herein, we successfully switched a patient with acromegaly from a dipeptidyl peptidase-4 (DPP-4) inhibitor to a glucagon-like peptide-1 (GLP-1) analog due to pasireotide-induced deterioration of glycemic control, and we examined the underlying mechanism for glycemic control
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