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Following FOXO4 displacement, the released p53 undergoes nuclear export and mitochondrial translocation, activating the intrinsic apoptosis pathway via BAX upregulation and BCL-2 downregulation, culminating in caspase-3 cleavage and apoptotic cell death

Lipo refers to fat, and tropic means to stimulate or enhance a particular function

Metabolic's parent company, Calzada Ltd, has had to deny it was involved in a secret drug trial involving four Essendon players and claims the case notes, from Dank, were to support a patent application and not for any use in a clinical trial

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