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The insulin resistance concern disqualifies it from metabolic research in anyone over 50 or with BMI above 27
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But "modest effects in animal studies" is an enormous distance from "clinically meaningful weight loss in humans." The gap between preclinical promise and proven human results is where most supplement claims fall apart
doi: 10.1038/s41569-018-0119-4 108 HeuvelmanVDVan RaalteDHSmitsMM
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