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Bile Duct Hyperplasia (Figures 119122) Pathogenesis A spontaneous change in portal areas of older animals

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Although Bbs5 / mice showed no differences in body weight at weaning compared to age-matched WT or heterozygous littermate controls, the KO mice began gaining adiposity at a significantly faster rate after 4 weeks of age, eventually becoming visibly larger than mice in both control groups (Figure 1A) Bbs5 / mice exhibited significant hyperphagia in both the light and dark phases compared with WT controls (Figure 1B), leading to increased body weight from 8 weeks of age (Figure 1C) and fat mass compared with WT littermate controls starting from 6 weeks of age (Figure 1D)