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Applied right after microneedling, GHK-Cu reaches the dermis through the channels created by the needles, bypassing the stratum corneum barrier
It is not FDA-approved for human use
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In dextran sulphate sodium (DSS)-induced colitis mice, the most commonly used preclinical IBD model, injected MOTS-c significantly reduced colon shortening and histological damage, lowered pro-inflammatory cytokines and plasma myeloperoxidase, and curbed macrophage and neutrophil activity
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