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To evaluate the impact of these NRF2 target genes on TNBC prognosis, we plotted the significance (log 10 of p-values) of logrank tests for DEGs downregulated by Cyss depletion using the Kaplan-Meier plotter platform and based on relapse-free survival ( RFS) and distant metastasis-free survival (DMFS) as endpoints of patients with TNBC and ER+/PR+, ER+/PR, and ER/PR/Her+ non-TNBC [27]
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Interestingly, the GPX4 inhibitor RSL3 can impair the maturation and function of DCs in tumor suppression by activating PPARG/PPAR (peroxisome oroliferator activated receptor gamma)-dependent ferroptosis in DC2.4 cell line [195] (Fig
