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Graves orbitopathy (GO) is the most prominent and common extrathyroidal manifestation of GD, characterized by the production and accumulation of glycosaminoglycans (especially hyaluronic acid) in the retrobulbar and periorbital tissues causing protrusion of the eyeball and restriction of ocular muscle movement ( Table 1
Furthermore, rapamycin-treated CAR T cells had significantly higher in vivo expansion, with absolute CAR+ cell counts in the peripheral blood of mice reaching a mean of tenfold higher compared with untreated CAR T cells on day 14 post injection (Fig
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