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The groundbreaking 2021 clinical trial of semaglutide still found that almost 14% of participants failed to even lose 5% of their body weight, even after taking the drug for more than one year
Large trials like SELECT, STEP, and PIONEER 7 suggest that with proper medical oversight, semaglutide can be used safely over months or even years
PCOS patients experience the same side-effect profile as other populations: nausea, constipation, and reduced appetite during dose escalation, typically resolving within 48 weeks
Clinical manifestations of hypothyroidism secondary to Hashimoto's disease include: Fatigue and lethargy Weight gain despite normal appetite Cold intolerance Dry skin and hair loss Constipation Depression and cognitive impairment Bradycardia and elevated cholesterol Diagnosis is established through thyroid function tests showing elevated thyroid-stimulating hormone (TSH) with low free T4 (overt hypothyroidism) or normal free T4 (subclinical hypothyroidism), alongside positive thyroid antibodies
