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Of the 48 inter-molecular NOE restraints, only 2 NOEs could be assigned unambiguously and correspond to contacts between p53-Trp53 HE# - FOXO4-Leu160 HD# and p53-Trp53 HD#FOXO4-Leu109 HD# (Supplementary Note 1)

It was added to the Prohibited List in 2022 as a non-approved substance, reflecting its transition from an obscure research compound to a significant "substance of interest" in professional athletics

While AOD-9604 has shown minimal interactions in studies, individual situations vary, particularly when multiple medications are involved

iii) High risk: Three or more criteria rated as unclear or at least two criteria not met