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The authors highlight biological plausibility, acknowledge limitations of retrospective administrative data, and call for randomized prospective trials to confirm causality and optimize treatment strategies

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Here is how it works: the enzyme carnitine palmitoyltransferase I (CPT-I) on the outer mitochondrial membrane converts fatty acyl-CoA to fatty acylcarnitine by attaching it to a carnitine molecule

Studies were categorized according to the duration of therapy, with the majority reporting outcomes after a 6-month follow-up period