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However, their therapeutic potential is limited by rapid metabolism and poor bioavailability

its blockade increases serotonin release Promotes neurogenesis : TREK-1 knockout mice show increased hippocampal neurogenesis, and PE-22-28 recapitulates this effect pharmacologically within 4 days of treatment Induces synaptogenesis : TREK-1 blockade promotes dendritic growth and synaptic connection formation PE-22-28 inhibits TREK-1 with an IC50 of 0.12 nM, making it approximately 300-500 times more potent than spadin

Above the high-risk line (300 ug/mL at 4 hours) indicates a high risk of liver failure (massive ingestion), which may warrant even more aggressive therapy (discussed below)

However, its important to know what minor issues could pop up and how to use peptides safely