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By way of example, sequential administration of 25 mg or 50 mg of sildenafil followed by 7.5 mg or 10 mg of IN PT-141 will produce a desired pharmacological response in a patient comparable to monotherapy with either 100 mg of sildenafil or 20 mg of IN PT-141 , but without the frequency or severity of side effects or adverse events generally observed with monotherapy with either 100 mg of sildenafil or 20 mg of IN PT-141