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Matt Kaeberlein (UW Medicine, Optispan) observed: Expecting a single drug to meaningfully alter the course of Alzheimers once cognitive decline is underway is an extraordinarily high bar. The EVOKE population already had MCI or mild dementiameaning pathological cascades were well-established

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Counts SE, Perez SE, Ginsberg SD, Mufson EJ (2010) Neuroprotective role for galanin in Alzheimers disease