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After virus entry in the CNS, it infects and replicates in microglia that acquire inflammatory phenotype, inducing a neurological damages [7]
Use of DPP-4 inhibitors, GLP-1 receptor agonists, and SGLT-2 inhibitors is on the rise owing, at least in part, to their glycemic benefits, lack of weight gain, and complementary mechanisms of action when used in combination with metformin or other antihyperglycemic medication classes
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Because of the ever-expanding use of GLP-1 receptor agonists, the availability of an oral agent within this therapeutic class has the potential to further increase GLP-1 receptor agonist use and provide an alternative route of administration for patients unable or unwilling to take SC injections
