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3.2.3 Ferroptosis and multiple sclerosis MS is an autoimmune-mediated NDD characterized by abnormal activation of immune cells, leading to myelin loss, axonal degeneration, and astrocyte proliferation

In this investigation, we initially identified oridonin as a direct covalent inhibitor of GSH, setting it apart from other drugs that disrupt ROS by targeting proteins both upstream and downstream of GSH

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