semaglutide def Tirzepatide vs. Semaglutide: Which Is Better For You ? Benefits of Semaglutide GLP-1 Injections

Martin MN et al

Giesbertz P, Ecker J, Haag A, Spanier B, Daniel H

Clinicians should: Assess baseline HbA1c and current glycemic control before discontinuation Implement or intensify alternative therapies (metformin, SGLT2 inhibitors, or other agents) before or concurrent with tirzepatide cessation Increase home glucose monitoring frequency for several weeks post-discontinuation Schedule follow-up to evaluate metabolic stability Special consideration for insulin or sulfonylurea users : Patients taking these medications alongside tirzepatide may need proactive dose adjustments when stopping tirzepatide to prevent hypoglycemia

Current studies indicate a manageable risk profile