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15% Patients lost an average of 15% of their body weight in ~1 year.* *In a 68-week double-blind trial studying once-weekly semaglutide injections (2.4 mg) in 1,961 patients without diabetes and with BMI 30, or BMI 27 with a weight-related condition, the average weight loss was 15%, when paired with diet and exercise changes

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Efficacy and safety of sitagliptin versus glipizide in patients with type 2 diabetes and moderate-to-severe chronic renal insufficiency

Body composition changes particularly fat loss and lean mass improvements typically become apparent over 812 weeks of consistent use, with continued progress through 6 months