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Preclinical studies report approximately 1.6 increases in intracellular NAD+ following NNMT inhibition in adipocyte models

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Key findings from cartilage research [7] : In vivo experiments used collagenase-induced osteoarthritis rabbit models Intra-articular AOD9604 injections enhanced cartilage regeneration Morphological assessments showed significantly improved cartilage structure Reduced degeneration scores compared to control groups Combined treatment with hyaluronic acid produced additive positive effects superior to either agent alone Chondrocyte Stimulation Studies Research suggests AOD9604 may promote differentiation of myoblasts and stimulate chondrocytes to produce extracellular matrix components [7]

However, the NHS provides a general recommendation of about 1.5g per day of B12 for adults