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Both groups appear to be throwing just about every compound they can think of up the noses of their laboratory rodent models, and some compounds are making it to human trials as well
LY3437943 (Retatrutide): discovery to clinical proof of concept (triple GLP-1/GIP/glucagon agonist, preclinical mechanism) Nature Reviews Endocrinology (2024) Multi-receptor agonists for metabolic disease (mechanism of GLP-1/GIP/glucagon co-activation) Diabetes Care (2024) Incretin-based therapies: GLP-1, GIP, and glucagon receptor pharmacology (metabolic pathways, energy expenditure) NEJM (2023) Supplementary Material Jastreboff et al
Thick mucus in ALS: a mixed-method study on associated factors and its impact on quality of life of patients and caregivers
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