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Consequently, a significant proportion of administered nanocarriers is prematurely sequestered and cleared by the reticuloendothelial system (RES)particularly the liver and spleensubstantially limiting the effective dose that reaches the osteosarcoma TME (69, 70)
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10.1038/gt.2008.178 277
Understanding the protective effects of SGLT2 inhibitors in type 2 diabetes patients with chronic kidney disease
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