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Although the mRNA abundance of hepatic Gck , the enzyme that phosphorylates glucose to produce glucose-6-phosphate, was significantly upregulated in Dpp4 / mice compared with livers of control mice (Figure 1E), transcript levels of the gluconeogenic enzymes, Pck and G6p , were unchanged (Figure 1E)
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Preparation of amino acid aminoheterocyclyl amides as melanocortin receptor agonists
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