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These drugs, originally approved for type 2 diabetes, lower A1c, slow digestion to increase satiety, increase fat utilization, and have led to dramatic weight loss results of around 12%17% of body weight after 48 weeks of use
Top-line outcomes: STEP 4 maintenance data is particularly relevant for researchers modelling discontinuation effects: participants who stopped Semaglutide regained approximately two-thirds of lost weight within 1 year, while those continuing maintained their loss, supporting the hypothesis that chronic GLP-1R engagement is required for sustained metabolic effects
For some people, you may not need the highest dose for weight loss maintenance
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