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A large-scale genome-wide association study published in Nature in April 2026, conducted by 23andMe researchers using data from 27,885 GLP-1 medication users, identified a specific variant in the GLP1R gene the gene that encodes the primary receptor these drugs target associated with differential weight loss efficacy
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Also, because GLP-1 drugs engage the brains reward circuitry the same system that governs not just craving but everyday motivation prolonged use could, in theory, dampen motivational drive in some people
Systemic administrations of a cannabis hydroalcoholic extract, an endocannabinoid analog, or a CB 1 receptor agonist increased blood ghrelin concentrations in rats 83,84
