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10.1007/s11357-012-9419-5 Age 10 BrazoV.SantelloF.ColatoR.DuarteA.GoulartA.SampaioP.et al (2020)

Objectives Based on the above findings, the purpose of this study was to evaluate the potential effects of sildenafil and vitamin E, both individually and in combination, on CP-induced hepatotoxicity in rats, along with investigating specific underlying mechanisms

Clinically Proven Strategies to Improve Side Effects Slow Dose Titration Instead of splitting doses, the proven strategy for minimizing side effects is gradual dose titrationstarting low and increasing slowly

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